Endocrine Abstracts

HPA response to glucocorticoids (GCs) feedback is usually tested by dexamethasone (DEX), a synthetic GC; it poorly crosses BBB and preferentially activates pituitaric glucocorticoid receptor (GR), with a binding potency to GR 7 fold higher and an anti-inflammatory potency about 35 fold higher than cortisol. Cortisol, which easily penetrates into CNS, could better evaluate the GC feedback by acting also at supra-pituitary level. We studied the effects of 150 min infusion of hyd...

Semen quality and reproductive hormones may be affected in men with testicular neoplasia (TN) and lymphoproliferative disorders (LD). We evaluated these parameters before, 6, 12 and 24 months after the end of the oncological treatments in 60 patients with TN, and in 35 patients with LD. The patients were divided on the bases of the basal sperm concentration (A< and B≥ 10 million/ml). FSH, LH, testosterone (T) and inhibin B levels and sperm parameters were evaluated i...